[EMERGING]Emerging
Time-series and clinical-trial data reported on illness in water-damaged building occupants
A combined time-series and clinical-trial report described multi-system symptoms and biomarker changes in occupants of water-damaged buildings, with changes reported on removal from exposure and treatment.
How to read this
This library reports what studies found. An entry describes a study's design, its findings in its own terms, and its limits. Nothing here is a claim about what a Sage Co. home does, delivers, or prevents.
Last reviewed August 30, 2026.
What they studied
- Case series and time-series follow-up of patients reporting illness after occupancy of water-damaged buildings.
- Measurement of a panel of inflammatory and neuroendocrine biomarkers.
- A clinical trial component evaluating response to a treatment protocol and to re-exposure.
What they found
- The author reported a multi-symptom, multi-system illness pattern among the studied occupants.
- Biomarker abnormalities were reported alongside symptom reports and were reported to change with removal from exposure.
- Symptom recurrence on re-exposure was reported in the trial component.
What this study does not establish
- Single-investigator case and trial data with limited independent replication in the cited literature.
- Participants were self-selected patients, not a general population sample.
- The biomarker panel and case definition described here are not universally accepted diagnostic criteria.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Shoemaker RC, House DE (2006). Sick building syndrome (SBS) and exposure to water-damaged buildings: time series study, clinical trial and mechanisms. Neurotoxicology and Teratology 28(5):573–588.
occupant illnessbiomarkersclinical
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