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Lung inflammation measured in mice exposed to Aspergillus versicolor spores from a moisture-damaged building
Mice exposed to Aspergillus versicolor spores collected from a moisture-damaged building showed dose-dependent acute lung inflammation that persisted at higher doses.
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This library reports what studies found. An entry describes a study's design, its findings in its own terms, and its limits. Nothing here is a claim about what a Sage Co. home does, delivers, or prevents.
Last reviewed August 30, 2026.
What they studied
- Aspergillus versicolor spores isolated from the indoor air of a moisture-damaged building.
- Intratracheal instillation into mice at graded doses.
- Measurement of inflammatory cells, cytokines, and lung histopathology over 28 days.
What they found
- Dose-dependent acute inflammatory responses were reported in the exposed animals.
- At higher doses, inflammatory changes were reported to persist beyond 28 days.
- The spores used were building isolates rather than laboratory reference strains.
What this study does not establish
- An animal instillation study; exposure route and dose differ from occupant inhalation.
- Single fungal species tested in isolation.
- No human outcomes measured.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R (2002). Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs. Inhalation Toxicology 14(12):1261–1277.
Aspergillus versicoloranimal modelrespiratoryinflammation
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