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Human brain cell responses measured at satratoxin concentrations reported from water-damaged buildings
Human brain-derived cell cultures exposed to satratoxin H at concentrations the authors drew from water-damaged building measurements showed activation of inflammatory and apoptotic pathways.
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This library reports what studies found. An entry describes a study's design, its findings in its own terms, and its limits. Nothing here is a claim about what a Sage Co. home does, delivers, or prevents.
Last reviewed August 30, 2026.
What they studied
- Human brain capillary endothelial cells, astrocytes, and neural progenitor cells in culture.
- Exposure to satratoxin H at concentrations reported from water-damaged building sampling.
- Measurement of inflammatory and apoptotic pathway activation.
What they found
- The authors reported sustained activation of inflammatory and apoptotic signaling in the exposed cells.
- Effects were reported at the environmentally derived concentrations tested.
- Multiple brain cell types were reported to respond.
What this study does not establish
- Cell culture, not an intact nervous system or a person.
- Applying a concentration measured in building material or air to cells in a dish is a modeling assumption, not a measured tissue dose.
- No clinical or cognitive outcome was measured.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Karunasena E, Larrañaga MD, Simoni JS, Douglas DR, Straus DC (2010). Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment. Mycopathologia 170(6):377–390.
in vitrohuman cellssatratoxinneurological
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