[EMERGING]Emerging
Immune response measured after single versus repeated Stachybotrys lung exposures in mice
In mice, a single Stachybotrys chartarum lung exposure produced acute neutrophilic inflammation while repeated exposures over seven weeks produced a different, eosinophil-associated pattern.
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Last reviewed August 30, 2026.
What they studied
- Mice exposed to Stachybotrys chartarum spores by lung instillation, either once or repeatedly over seven weeks.
- Measurement of inflammatory cell populations, cytokines, and lung histopathology.
- Comparison of acute and chronic exposure patterns.
What they found
- A single exposure was reported to produce acute neutrophil-dominant inflammation.
- Repeated exposures were reported to produce eosinophil-rich granulomas, goblet cell metaplasia, and elevated IL-4, IL-5, and IL-13.
- The authors reported that the response pattern changed with repetition rather than simply increasing in magnitude.
What this study does not establish
- An animal model using instilled spores, not ambient inhalation.
- Mouse immune responses do not translate directly to humans.
- Doses and intervals were experimental, not modeled on occupant exposure.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu Y-H, Mathews JA, Kasahara DI, Park J-A, Bordini A, Godleski JJ, Gillis BS, Brain JD (2016). Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. American Journal of Respiratory Cell and Molecular Biology 55(4):521–531.
Stachybotrysanimal modelimmune responserepeated exposure
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