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Inflammatory response in mice after instillation of Streptomyces spores from a moldy building
Mice given intratracheal Streptomyces californicus spores isolated from indoor air of a moldy building showed dose-dependent lung inflammation.
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This library reports what studies found. An entry describes a study's design, its findings in its own terms, and its limits. Nothing here is a claim about what a Sage Co. home does, delivers, or prevents.
Last reviewed August 30, 2026.
What they studied
- An animal experiment using Streptomyces californicus spores isolated from the indoor air of a moisture-damaged building.
- Spores were instilled intratracheally into mice at graded doses.
- Cytokine levels, inflammatory cell recruitment, and lung histopathology were measured.
What they found
- The authors reported dose-dependent elevations of TNF-alpha and IL-6 in the exposed mice.
- Inflammatory cell recruitment and acute histopathological lung changes were reported.
- Responses were reported for the bacterial spores alone, without fungal co-exposure.
What this study does not establish
- An animal study using intratracheal instillation, not inhalation of ambient building air.
- Doses were experimental and are not equivalent to occupant exposure levels.
- Findings in mice do not establish human health outcomes.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R (2001). Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californicus isolated from indoor air of a moldy building. Toxicology and Applied Pharmacology 171(1):61–69.
actinomycetesanimal modelinflammationrespiratory
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