[EMERGING]Emerging
Dopamine handling and neurodegeneration measured in model systems exposed to 1-octen-3-ol
In fruit fly and human cell models, the fungal volatile 1-octen-3-ol was reported to disrupt dopamine transport and produce dopaminergic neuron degeneration.
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Last reviewed August 30, 2026.
What they studied
- Drosophila melanogaster and human cell lines exposed to 1-octen-3-ol.
- Measurement of dopamine transporter and vesicular monoamine transporter function.
- Assessment of dopaminergic neuron degeneration and motor phenotypes in the fly model.
What they found
- The authors reported disrupted dopamine packaging via the vesicular monoamine transporter.
- Degeneration of dopaminergic neurons was reported in the fly model.
- The authors proposed the compound as a candidate environmental factor for further study in parkinsonism.
What this study does not establish
- Invertebrate and cell-culture models; results do not transfer directly to humans.
- Experimental exposure levels were not derived from measured indoor air.
- No human neurological outcome was measured.
- This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
Inamdar AA, Hossain MM, Bernstein AI, Miller GW, Richardson JR, Bennett JW (2013). Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. Proceedings of the National Academy of Sciences USA 110(48):19561–19566.
mVOCsin vitroDrosophilaneurological
Elsewhere under Indoor Air Quality
- Cognitive test scores measured against CO2, ventilation, and VOC levels in an office setting
- Toxicological review of microbial volatile organic compounds in moisture-damaged buildings
- Acute responses measured in a controlled human exposure to 1-octen-3-ol
- Classroom microbial VOC measurements compared against reported respiratory symptoms in pupils
- Measured dwelling microbial VOCs compared against sick building syndrome reports in three cities
- Review asking whether some fungal volatile compounds meet the definition of mycotoxins
- Airborne gram-negative bacteria and endotoxin measured across office buildings with differing symptom rates
- Proinflammatory mediators measured in cell lines exposed to indoor bacteria and fungal spores
- Dust fungi and endotoxin measured against respiratory symptoms in a water-damaged office building
- Chemical marker analysis used to detect microbial colonization in water-damaged building materials
- Endotoxin, ergosterol, muramic acid, and fungal DNA measured in school dust against rhinitis reports
- Airborne macrocyclic trichothecene mycotoxins measured in water-damaged indoor environments
- Satratoxin G and H measured in indoor air of a water-damaged dwelling
- Mycotoxin survey of building material samples from water-damaged buildings
- Systematic review of airborne mycotoxin exposure across environments and tasks