Time-series and clinical-trial data reported on illness in water-damaged building occupants
Shoemaker RC, House DE (2006) · Neurotoxicology and Teratology 28(5):573–588
A combined time-series and clinical-trial report described multi-system symptoms and biomarker changes in occupants of water-damaged buildings, with changes reported on removal from exposure and treatment.
What they studied
Case series and time-series follow-up of patients reporting illness after occupancy of water-damaged buildings.
Measurement of a panel of inflammatory and neuroendocrine biomarkers.
A clinical trial component evaluating response to a treatment protocol and to re-exposure.
What they found
The author reported a multi-symptom, multi-system illness pattern among the studied occupants.
Biomarker abnormalities were reported alongside symptom reports and were reported to change with removal from exposure.
Symptom recurrence on re-exposure was reported in the trial component.
What it does not establish
Single-investigator case and trial data with limited independent replication in the cited literature.
Participants were self-selected patients, not a general population sample.
The biomarker panel and case definition described here are not universally accepted diagnostic criteria.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Shoemaker RC, House DE (2006). Sick building syndrome (SBS) and exposure to water-damaged buildings: time series study, clinical trial and mechanisms · Neurotoxicology and Teratology 28(5):573–588 · Read at the source
Last reviewed August 30, 2026.