Inflammatory response in mice after instillation of Streptomyces spores from a moldy building
Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R (2001) · Toxicology and Applied Pharmacology 171(1):61–69
Mice given intratracheal Streptomyces californicus spores isolated from indoor air of a moldy building showed dose-dependent lung inflammation.
What they studied
An animal experiment using Streptomyces californicus spores isolated from the indoor air of a moisture-damaged building.
Spores were instilled intratracheally into mice at graded doses.
Cytokine levels, inflammatory cell recruitment, and lung histopathology were measured.
What they found
The authors reported dose-dependent elevations of TNF-alpha and IL-6 in the exposed mice.
Inflammatory cell recruitment and acute histopathological lung changes were reported.
Responses were reported for the bacterial spores alone, without fungal co-exposure.
What it does not establish
An animal study using intratracheal instillation, not inhalation of ambient building air.
Doses were experimental and are not equivalent to occupant exposure levels.
Findings in mice do not establish human health outcomes.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Jussila J, Komulainen H, Huttunen K, Roponen M, Hälinen A, Hyvärinen A, Kosma V-M, Pelkonen J, Hirvonen M-R (2001). Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californicus isolated from indoor air of a moldy building · Toxicology and Applied Pharmacology 171(1):61–69 · Read at the source
Last reviewed August 30, 2026.