Human brain cell responses measured at satratoxin concentrations reported from water-damaged buildings
Karunasena E, Larrañaga MD, Simoni JS, Douglas DR, Straus DC (2010) · Mycopathologia 170(6):377–390
Human brain-derived cell cultures exposed to satratoxin H at concentrations the authors drew from water-damaged building measurements showed activation of inflammatory and apoptotic pathways.
What they studied
Human brain capillary endothelial cells, astrocytes, and neural progenitor cells in culture.
Exposure to satratoxin H at concentrations reported from water-damaged building sampling.
Measurement of inflammatory and apoptotic pathway activation.
What they found
The authors reported sustained activation of inflammatory and apoptotic signaling in the exposed cells.
Effects were reported at the environmentally derived concentrations tested.
Multiple brain cell types were reported to respond.
What it does not establish
Cell culture, not an intact nervous system or a person.
Applying a concentration measured in building material or air to cells in a dish is a modeling assumption, not a measured tissue dose.
No clinical or cognitive outcome was measured.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Karunasena E, Larrañaga MD, Simoni JS, Douglas DR, Straus DC (2010). Building-associated neurological damage modeled in human cells: a mechanism of neurotoxic effects by exposure to mycotoxins in the indoor environment · Mycopathologia 170(6):377–390 · Read at the source
Last reviewed August 30, 2026.