Olfactory neuron loss and inflammation measured in mice after intranasal satratoxin G
Islam Z, Harkema JR, Pestka JJ (2006) · Environmental Health Perspectives 114(7):1099–1107
Intranasal satratoxin G in mice was reported to cause dose-dependent olfactory sensory neuron loss, rhinitis, and cytokine expression extending to the olfactory bulb.
What they studied
Mice given intranasal satratoxin G at graded single doses and in repeated low doses.
Histopathology of nasal airways and olfactory bulb.
Measurement of proinflammatory cytokine gene expression.
What they found
Dose-dependent apoptosis of olfactory sensory neurons was reported.
Acute rhinitis and proinflammatory cytokine expression were reported in the nasal airways and olfactory bulb.
Repeated low-dose exposure was reported to produce cumulative effects comparable to single high doses.
What it does not establish
An animal study using purified toxin, not building air.
Instilled doses are not equivalent to inhaled residential exposures.
Findings do not establish human neurological outcomes.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Islam Z, Harkema JR, Pestka JJ (2006). Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain · Environmental Health Perspectives 114(7):1099–1107 · Read at the source
Last reviewed August 30, 2026.