Nasal and olfactory effects of satratoxin G measured in rhesus monkeys
Carey SA, Plopper CG, Hyde DM, Islam Z, Pestka JJ, Harkema JR (2012) · Toxicologic Pathology 40(6):887–898
In a primate model, single high-dose and repeated low-dose intranasal satratoxin G were reported to produce rhinitis and loss of olfactory sensory neurons.
What they studied
Rhesus macaques given intranasal satratoxin G, a trichothecene produced by Stachybotrys chartarum.
Both a single high-dose regimen and a repeated low-dose regimen.
Histopathology of the nasal airways and olfactory epithelium.
What they found
The authors reported rhinitis in both dosing regimens.
Atrophy of the olfactory epithelium and apoptosis of olfactory sensory neurons were reported.
Repeated low-dose exposure was reported to produce effects comparable to the single high dose.
What it does not establish
An experimental animal study using purified toxin instilled intranasally.
Doses were selected experimentally and do not correspond to measured building air concentrations.
No human exposure or outcome was measured.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Carey SA, Plopper CG, Hyde DM, Islam Z, Pestka JJ, Harkema JR (2012). Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys · Toxicologic Pathology 40(6):887–898 · Read at the source
Last reviewed August 30, 2026.