Immune response measured after single versus repeated Stachybotrys lung exposures in mice
Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu Y-H, Mathews JA, Kasahara DI, Park J-A, Bordini A, Godleski JJ, Gillis BS, Brain JD (2016) · American Journal of Respiratory Cell and Molecular Biology 55(4):521–531
In mice, a single Stachybotrys chartarum lung exposure produced acute neutrophilic inflammation while repeated exposures over seven weeks produced a different, eosinophil-associated pattern.
What they studied
Mice exposed to Stachybotrys chartarum spores by lung instillation, either once or repeatedly over seven weeks.
Measurement of inflammatory cell populations, cytokines, and lung histopathology.
Comparison of acute and chronic exposure patterns.
What they found
A single exposure was reported to produce acute neutrophil-dominant inflammation.
Repeated exposures were reported to produce eosinophil-rich granulomas, goblet cell metaplasia, and elevated IL-4, IL-5, and IL-13.
The authors reported that the response pattern changed with repetition rather than simply increasing in magnitude.
What it does not establish
An animal model using instilled spores, not ambient inhalation.
Mouse immune responses do not translate directly to humans.
Doses and intervals were experimental, not modeled on occupant exposure.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu Y-H, Mathews JA, Kasahara DI, Park J-A, Bordini A, Godleski JJ, Gillis BS, Brain JD (2016). Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2 · American Journal of Respiratory Cell and Molecular Biology 55(4):521–531 · Read at the source
Last reviewed August 30, 2026.