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Proinflammatory mediators measured in cell lines exposed to indoor bacteria and fungal spores

Huttunen K, Hyvärinen A, Nevalainen A, Komulainen H, Hirvonen M-R (2003) · Environmental Health Perspectives 111(1):85–92

In mouse and human cell lines, a gram-negative bacterium isolated indoors produced stronger inflammatory mediator responses than the indoor fungi tested alongside it.

What they studied

Three bacterial and three fungal species isolated from indoor environments.

Exposure of mouse macrophage and human cell lines to each organism.

Measurement of TNF-alpha, IL-6, and IL-1beta production.

What they found

Pseudomonas fluorescens was reported as the strongest inducer of the measured cytokines.

Its measured responses exceeded those from Stachybotrys chartarum and Aspergillus versicolor in these assays.

Response magnitude was reported to vary by organism and cell line.

What it does not establish

Cell-line assays, not intact airways or occupied buildings.

Exposure doses were experimental, not measured indoor concentrations.

Cytokine production is not a clinical outcome.

This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.

Source

  • Huttunen K, Hyvärinen A, Nevalainen A, Komulainen H, Hirvonen M-R (2003). Production of proinflammatory mediators by indoor air bacteria and fungal spores in mouse and human cell lines · Environmental Health Perspectives 111(1):85–92 · Read at the source

Last reviewed August 30, 2026.

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