Systematic review of fungal exposure and hypersensitivity pneumonitis
Dias P, Matos C, Apolinario D (2021) · Porto Biomedical Journal 6(1):e117
A systematic review reported that Penicillium and Aspergillus were the fungi most frequently identified in cases of hypersensitivity pneumonitis, often in association with moisture-damaged buildings.
What they studied
A PRISMA systematic review of published studies linking fungal exposure to hypersensitivity pneumonitis.
Cases from residential, occupational, and HVAC-associated exposures.
Reported fungal genera, exposure settings, and disease course.
What they found
Penicillium and Aspergillus were reported as the genera most frequently associated with disease onset in the reviewed literature.
Hypersensitivity pneumonitis was reported to account for a minority share of interstitial lung disease cases in the cited sources.
The reviewed literature reported that the condition can progress to pulmonary fibrosis in some cases.
What it does not establish
Case-based literature; exposure characterization varies widely between reports.
The review does not establish incidence in the general population.
Association with a genus does not identify a causal agent or exposure threshold.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Dias P, Matos C, Apolinario D (2021). The association between fungi exposure and hypersensitivity pneumonitis: a systematic review · Porto Biomedical Journal 6(1):e117 · Read at the source
Last reviewed August 30, 2026.