Inflammatory gene expression measured in macrophages exposed to toxins from damp-building fungi
Rand TG, Chang CT, McMullin DR, Miller JD (2017) · Toxicology In Vitro 43:16–20
Purified toxins from five fungi common on damp building materials each produced distinct inflammatory gene-expression profiles in a macrophage cell line.
What they studied
Seven purified toxins produced by five fungi found on damp building materials, including Chaetomium globosum, Wallemia sebi, Penicillium corylophilum, and Trichoderma species.
Exposure of RAW 264.7 macrophages at concentrations the authors calibrated to indoor inhalation scenarios.
Measurement of inflammation-associated gene expression.
What they found
All tested compounds were reported to alter inflammation-associated gene expression.
Each compound was reported to produce a distinct expression signature.
Responses were reported at the concentrations selected as indoor-relevant by the authors.
What it does not establish
A cell-line study; it does not measure responses in an intact airway or in people.
Concentration selection is a modeling assumption, not a measured occupant dose.
Gene expression changes are not clinical outcomes.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Rand TG, Chang CT, McMullin DR, Miller JD (2017). Inflammation-associated gene expression in RAW 264.7 macrophages induced by toxins from fungi common on damp building materials · Toxicology In Vitro 43:16–20 · Read at the source
Last reviewed August 30, 2026.