Lung inflammation measured in mice exposed to Aspergillus versicolor spores from a moisture-damaged building
Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R (2002) · Inhalation Toxicology 14(12):1261–1277
Mice exposed to Aspergillus versicolor spores collected from a moisture-damaged building showed dose-dependent acute lung inflammation that persisted at higher doses.
What they studied
Aspergillus versicolor spores isolated from the indoor air of a moisture-damaged building.
Intratracheal instillation into mice at graded doses.
Measurement of inflammatory cells, cytokines, and lung histopathology over 28 days.
What they found
Dose-dependent acute inflammatory responses were reported in the exposed animals.
At higher doses, inflammatory changes were reported to persist beyond 28 days.
The spores used were building isolates rather than laboratory reference strains.
What it does not establish
An animal instillation study; exposure route and dose differ from occupant inhalation.
Single fungal species tested in isolation.
No human outcomes measured.
This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.
Source
- Jussila J, Komulainen H, Kosma V-M, Nevalainen A, Pelkonen J, Hirvonen M-R (2002). Spores of Aspergillus versicolor isolated from indoor air of a moisture-damaged building provoke acute inflammation in mouse lungs · Inhalation Toxicology 14(12):1261–1277 · Read at the source
Last reviewed August 30, 2026.