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Dopamine handling and neurodegeneration measured in model systems exposed to 1-octen-3-ol

Inamdar AA, Hossain MM, Bernstein AI, Miller GW, Richardson JR, Bennett JW (2013) · Proceedings of the National Academy of Sciences USA 110(48):19561–19566

In fruit fly and human cell models, the fungal volatile 1-octen-3-ol was reported to disrupt dopamine transport and produce dopaminergic neuron degeneration.

What they studied

Drosophila melanogaster and human cell lines exposed to 1-octen-3-ol.

Measurement of dopamine transporter and vesicular monoamine transporter function.

Assessment of dopaminergic neuron degeneration and motor phenotypes in the fly model.

What they found

The authors reported disrupted dopamine packaging via the vesicular monoamine transporter.

Degeneration of dopaminergic neurons was reported in the fly model.

The authors proposed the compound as a candidate environmental factor for further study in parkinsonism.

What it does not establish

Invertebrate and cell-culture models; results do not transfer directly to humans.

Experimental exposure levels were not derived from measured indoor air.

No human neurological outcome was measured.

This entry reports the study. It is not a statement about any building Sage Co. designs or constructs.

Source

  • Inamdar AA, Hossain MM, Bernstein AI, Miller GW, Richardson JR, Bennett JW (2013). Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration · Proceedings of the National Academy of Sciences USA 110(48):19561–19566 · Read at the source

Last reviewed August 30, 2026.

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